1LD7: Co-crystal structure of Human Farnesyltransferase with farnesyldiphosphate and inhibitor compound 66

PDB ID: 1LD7Download
MMDB ID: 19949
PDB Deposition Date: 2002/4/8
Updated in MMDB: 2007/10
Experimental Method:
x-ray diffraction
Resolution: 2  Å
Source Organism:
Similar Structures:
Biological Unit for 1LD7: dimeric; determined by author and by software (PISA)
Molecular Components in 1LD7
Label Count Molecule
Proteins (2 molecules)
1
Protein Farnesyltransferase Alpha Subunit
(Gene symbol: FNTA)
Molecule annotation
1
Protein Farnesyltransferase Beta Subunit
(Gene symbol: FNTB)
Molecule annotation
Chemicals and Non-standard biopolymers (5 molecules)
1
1
alpha-D-glucopyranosealpha-D-glucopyranose
2
1
beta-D-fructofuranosebeta-D-fructofuranose
3
1
ZINC IONZINC ION
4
1
FARNESYL DIPHOSPHATEFARNESYL DIPHOSPHATE
5
1
(20S)-19,20,22,23-TETRAHYDRO-19-OXO-5H,21H-18,20-ETHANO-12,14-ETHENO-6,10-METHENOBENZ[D]IMIDAZO[4,3-L][1,6,9,13]OXATRIA ZACYCLONOADECOSINE-9-CARBONITRILE(20S)-19,20,22,23-TETRAHYDRO-19-OXO-5H,21H-18,20-ETHANO-12,14-ETHENO-6,10-METHENOBENZ[D]IMIDAZO[4,3-L][1,6,9,13]OXATRIA ZACYCLONOADECOSINE-9-CARBONITRILE
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303